納米生物光子學（Nanobiophotonics）是融合物理、化學、信息與生命科學的交叉學科，旨在利用光學與納米光子學的優勢，發展面向生命體系研究的新技術。典型技術包括光鑷、超分辨成像和納米光子學傳感等，在單分子、生物大分子及活細胞層面的操控、成像與分析中發揮着核心作用。近年來，随着納米材料與光學探測技術的進步，多功能納米光學探針不斷湧現，使納米尺度的溫度、力場及磁場成像成為可能，推動了生命科學與光學前沿的深度融合。然而，在複雜生物環境中實現對單顆粒和細胞器的高分辨成像與精确操控仍面臨挑戰。本團隊聚焦于研究和利用新型微納結構與材料的獨特光學性質，發展創新型生物光子學技術，以解決亞細胞生物物理研究中的關鍵科學問題。

目前團隊成員5人，包括1位國家級青年人才，1位教授，2位副教授和1位助理教授，團隊負責人王帆教授。以通訊作者發表文章100餘篇，含Nature Photonics, Nature Nanotechnology，Nature Protocols, Nature Communications，Light: Science & Applications，Optica，Nano Letters，和Advanced Materials。成果入選中國光學十大進展與中國光學十大社會影響力事件。主持多項國家自然科學基金，包含重點項目。成員受聘擔任APL Photonics 青年編委，Journal of Modern Optics編委，中國激光編委， Chinese Optics Letters編委，中國稀土學報青年編委。負責人王帆教授曾獲得澳大利亞青年學者獎（DECRA）、澳大利亞David Syme研究獎以及iCANX青年科學家獎。

主要研究方向：光鑷、超分辨成像、上轉換納米顆粒、微腔光子學

代表性成果：

1. Shan, X.; Ding, L.; Wang, D.; Wen, S.; Shi, J.; Chen, C.; Wang, Y.; Zhu, H.; Huang, Z.; Wang, S. S. J.; Wang, F. Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy. Nature Photonics, 18(9), 913–921 (2024).

2. Shan, X.; Wang, F.; Wang, D.; Wen, S.; Chen, C.; Di, X.; Nie, P.; Liao, J.; Liu, Y.; Ding, L.; Jin, D. Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles. Nature Nanotechnology, 16(5), 531–537 (2021).

3. Wang, F.; Wen, S.; He, H.; Wang, B.; Zhou, Z.; Shimoni, O.; Jin, D. Microscopic inspection and tracking of single upconversion nanoparticles in living cells. Light: Science & Applications, 7(4), 18007 (2018).

4. Tian, M.; Liu, B.; Lu, Z.; Wang, Y.; Zheng, Z.; Song, J.; Zhong, X.; Wang, F. Miniaturized on-chip spectrometer enabled by electrochromic modulation. Light: Science & Applications, 13(1), 278 (2024).

5. Lu, Z.; Hang, X.; Zhao, Z.; Cheng, L.; Zeng, Y.; Li, B.; Tian, M.; Liu, B.; Shan, X.; Zhu, H.; Wang, F. Photoenergy harvesting by ammonium molybdate soft hydrogel drops. Light: Science & Applications, 14(1), 372 (2025).

6. Chen, C.; Wang, F.; Wen, S.; Su, Q. P.; Wu, M. C. L.; Liu, Y.; Wang, B.; Li, D.; Shan, X.; Kianinia, M.; Jin, D. Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles. Nature Communications, 9(1), 3290 (2018).

7. Liu, Y.; Zhou, Z.; Wang, F.; Kewes, G.; Wen, S.; Burger, S.; Wakiani, M. E.; Xi, P.; Yang, J.; Yang, X.; Jin, D. Axial localization and tracking of self-interference nanoparticles by lateral point spread functions. Nature Communications, 12(1), 1–9 (2021).

8. Chen, C.; Liu, B.; Liu, Y.; Liao, J.; Shan, X.; Wang, F.; Jin, D. Heterochromatic nonlinear optical responses in upconversion nanoparticles for super-resolution nanoscopy. Advanced Materials, 33(23), 2008847 (2021).

9. Ding, L.; Chen, C.; Shan, X.; Liu, B.; Wang, D.; Du, Z.; Zhao, G.; Su, Q. P.; Yang, Y.; Halkon, B.; Jin, D. Optical nonlinearity enabled super-resolved multiplexing microscopy. Advanced Materials, 36(2), 2308844 (2024).

10. Lu, Z.; Zhu, H.; Wang, D.; Ma, M.; Wang, J.; Zhong, X.; Wang, F. Moisture-light harvesting enhanced hydrovoltaic electric generation. Advanced Materials, e15241 (2025).

11. Liu, B.; Wang, F.; Chen, C.; Dong, F.; McGloin, D. Self-evolving ghost imaging. Optica, 8(10), 1340–1349 (2021).

12. Ding, L.; Shan, X.; Wang, D.; Liu, B.; Du, Z.; Di, X.; Chen, C.; Maddahfar, M.; Zhang, L.; Shi, Y.; Jin, D. Lanthanide ion resonance–driven Rayleigh scattering of nanoparticles for dual-modality interferometric scattering microscopy. Advanced Science, 9(32), 2270207 (2022).

13. Li, X.; Wang, Y.; Shi, J.; Zhao, Z.; Wang, D.; Chen, Z.; Cheng, L.; Lu, G.-H.; Liang, Y.; Dong, H.; Wang, F. Large-area near-infrared emission enhancement on single upconversion nanoparticles by metal nanohole array. Nano Letters, 24(19), 5831–5837 (2024).

14. Song, J.; Liu, B.; Wang, Y.; Chen, C.; Shan, X.; Zhong, X.; Wu, L.-A.; Wang, F. Computational and dark-field ghost imaging with ultraviolet light. Photonics Research, 12(2), 226–234 (2024).

Wang, Y.; Liu, B.; Ding, L.; Chen, C.; Shan, X.; Wang, D.; Tian, M.; Song, J.; Zheng, Z.; Xu, X.; Wang, F. Multi-photon super-linear image scanning microscopy using upconversion nanoparticles. Laser & Photonics Reviews, 18(12), 2400746 (2024).